Predicting NSCLC Lymph Node Metastasis: Integrating ctDNA Mutation/ Methylation Profiling With PET-CT Scan: The LUNon-invasive Study
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY
This is a single center, prospective and observational study conducted in three stages to predict the NSCLC lymph node metastasis based on ctDNA/specific methylation molecular features combined with PET-CT imaging features and intervention study.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:
• Provision of informed consent prior to study initiation.
• Age between 18 and 75 years.
• Preoperative clinical evaluation indicating non-small cell lung cancer (NSCLC) stage I-IIIB (without initial treatment sought).
• Newly treated patients who have consented to undergo surgery.
• Eastern Cooperative Oncology Group (ECOG) performance status (PS) score of 0-1.
Locations
Other Locations
China
Shanghai Chest Hospital
RECRUITING
Shanghai
Contact Information
Primary
Feng Yao, PhD
yaofeng@shsmu.edu.cn
021-2220000
Time Frame
Start Date: 2023-12-15
Estimated Completion Date: 2027-12-31
Participants
Target number of participants: 200
Treatments
Blood ctDNA + methylation + PET-CT vs Postoperative pathology
MRD+ methylation (or combined with PET-CT) vs Invasive mediastinoscopy /EBUS-TBNA
Lymph Node dissection vs no lymph node dissection
Related Therapeutic Areas
Sponsors
Leads: Shanghai Chest Hospital